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pentobarbital improves toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. CYP3A4 inducers may well boost the metabolism of ifosfamide to its Lively alkylating metabolites.We report a situation of survival adhering to deliberate self-poisoning using a perhaps lethal dose of pentobarbital. In overdos